Genomic and transcriptomic characterization of desmoplastic small round cell tumors
نویسندگان
چکیده
منابع مشابه
Results of multimodal treatment for desmoplastic small round cell tumors.
PURPOSE Desmoplastic small round cell tumors (DSRCTs) are rare aggressive neoplasms that frequently present with large symptomatic intraabdominal masses. We examined the effects of multimodal therapy including induction chemotherapy, aggressive surgical debulking, and external beam radiotherapy on patients with DSRCT. METHODS Institutional Review Board permission was obtained. Sixty-six patie...
متن کاملDesmoplastic small round cell tumors in a young man.
A previously healthy 18-year-old man was admitted to our hospital with abdominal pain in September 2010. We performed a percutaneous biopsy of multiple intrahepatic masses. A diagnosis of desmoplastic small round cell tumors was confirmed based on the presence of a polyphenotypic immunoprofile (positivity for EMA, vimentin, cytokeratin, desmin and WT1) and characteristic EWS-WT1 gene fusion. Be...
متن کاملDesmoplastic Small Round Cell Tumor of Stomach
Desmoplastic small round cell tumor (DSRCT) is an extremely uncommon, highly aggressive, and malignant mesenchymal neoplasm of undetermined histogenesis. Less than 200 case reports have been documented in literature so far. Herein, we report a 26-year-old otherwise healthy female patient who presented with a 1-month history of epigastric pain. On physical examination, a palpable, slightly mobil...
متن کاملIntra-abdominal desmoplastic small round cell tumor
BACKGROUND The desmoplastic small round cell tumour is a rare and aggressive intra-abdominal neoplasia, with only 200 cases reported, and a higher incidence in men and predilection for the second decade of life. Histologically characterized by the presence of small nests of undifferentiated tumour cells, wrapped in fibrous desmoplastic stroma. CLINICAL CASE A 24 year old male started with abd...
متن کاملDesmoplastic small-round-cell rectal tumor
A 22-year-old male presented with abdominal and back pain and significant weight loss. On examination he was cachectic with a large palpable mass arising from the pelvis. A digital rectal exam revealed an obstructed rectal mass 5 cms from the anal verge. A contrast-enhanced computed tomography (CT) scan of the abdomen revealed a rectal mass with peritoneal metastasis in the form of extensive pe...
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ژورنال
عنوان ژورنال: Genes, Chromosomes and Cancer
سال: 2021
ISSN: 1045-2257,1098-2264
DOI: 10.1002/gcc.22955